Pathways of mutagenesis at (GAA)n trinucleotide repeats in dividing and quiescent Saccharomyces cerevisiae

Neil, Alexander.


  • The goal of this thesis is to examine how long repetitive DNA sequences comprised of (GAA)n trinucleotide repeats lead to genetic mutations. Understanding the mechanisms of mutagenesis at these sequences will aid in our understanding of the childhood-onset, neurodegenerative disease Friedreich's Ataxia (FRDA), which results from the inheritance of abnormally long (GAA)n repeats. In order to ... read more
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