Role of the Srs2 helicase and Ctf18 clamp loader in replication of structure-forming CAG repeats in S. cerevisiae

Nguyen, Jennifer.


  • Abstract: Our genome is riddled with repetitive sequences. While the functions of these repetitive sequences largely remain elusive, expansions of a subset of structure-forming microsatellites have been found to be associated with the onset of several neurodegenerative diseases. These repeat sequences pose a natural threat to the cell during replication and repair, forming barriers that can ... read more
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