Developing Inhibitors of Loop and Beta-Strand Mediated Protein-Protein Interactions through the Rational Design of Peptides

Bajpai, Ravi K.


  • Inhibitors of once undruggable protein-protein interactions are now an increasingly attainable target due to the development of peptide inhibitors. Cyclic peptides have been especially successful at inhibiting -helix mediated interactions since staples can be used to help mote helix formation without interrupting the binding of the residues need for the interaction. However, despite the advances ... read more
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