%0 PDF %T Trophoblast differentiation, invasion and hormone secretion in a three-dimensional in vitro implantation model with rhesus monkey embryos. %A Chang, T. Arthur.; Bondarenko, Gennadiy I.; Gerami-Naini, Behzad.; Drenzek, Jessica G.; Durning, Maureen.; Garthwaite, Mark A.; Schmidt, Jenna Kropp.; Golos, Thaddeus G. %D 2018-03-21T09:46:16.302-04:00 %8 2018-03-21 %R http://localhost/files/f7623r015 %X Background: The initiation of primate embryo invasion into the endometrium and the formation of the placenta from trophoblasts, fetal mesenchyme, and vascular components are essential for the establishment of a successful pregnancy. The mechanisms which direct morphogenesis of the chorionic villi, and the interactions between trophectoderm-derived trophoblasts and the fetal mesenchyme to direct these processes during placentation are not well understood due to a dearth of systems to examine and manipulate real-time primate implantation. Here we describe an in vitro three-dimensional (3-D) model to study implantation which utilized IVF-generated rhesus monkey embryos cultured in a Matrigel explant system.; Keywords: Embryo, Implantation, Trophoblast, Non-human primate.; Springer Open. %[ 2018-10-15 %9 Text %~ Tufts Digital Library %W Institution