Adoptive Immunotherapy for Chronic Myeloid Leukemia in a Mouse Model.

Lu, Yi-Fen.

2011

Description
  • Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by t(9;22) chromosomal translocation that creates the Philadelphia chromosome. The translocation encodes a constitutively active tyrosine kinase, BCR-ABL1, which turns a normal hematopoietic stem cell into a leukemic stem cell (LSC). BCR-ABL1 does not affect lineage differentiation. Therefore, CML is characterized cli... read more
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