GABRA2 POINT-MUTATION: INCREASED BINGE-LIKE AND BLUNTED DEPENDENCE-INDUCING ALCOHOL DRINKING BY MICE

Newman, Emily.

2017-04-19T18:07:25.741Z

Description
  • Abstract: Alcohol use disorders have been associated with SNPs in GABRA2, the gene encoding the GABAA receptor α2-subunit in humans. Deficient GABAergic functioning is linked to impulse control disorders including intermittent explosive disorder, and to drug abuse and dependence, yet it remains unclear if α2-containing GABAA receptor sensitivity to endogenous ligands is involved in excessive alcoh... read more
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