3 phosphorylation in autism spectrum disorders and neurosteroid activity.

Vien, Thuy N.


  • Abstract: Alterations in GABAAR 3 expression and function are linked to autism spectrum disorders (ASDs). Protein kinase C (PKC)-mediated phosphorylation of the 3 subunit on serine residues 408/9 (S408/9) shapes its membrane expression and GABAergic inhibition. To evaluate whether dysregulation of this process was involved in ASDs we assessed 3 phosphorylation in Fmr1 knockout mice, a widely accep... read more
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