A Pooled CRISPR/Cas9 screen to identify essential kinases for GBM stem cells.

Zhang, Yahan.


  • Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. GBM has a very poor prognosis, with a less than 10% 5-year survival rate. It is a WHO grade IV glioma which are significantly more proliferative, invasive, and angiogenic than lower grade gliomas. However, currently there is still no significant targeted therapeutic that is effective for GBM therapy. A subpopulation ... read more
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