Discovery of substrate cycles in large scale metabolic networks using hierarchical modularity.

Hassoun, Soha.

Sridharan, Gautham Vivek.

Ullah, Ehsan.

Lee, Kyongbum.

2015

Description
  • Background: A substrate cycle is a set of metabolic reactions, arranged in a loop, which does not result in net consumption or production of the metabolites. The cycle operates by transforming a cofactor, e.g. oxidizing a reducing equivalent. Substrate cycles have been found experimentally in many parts of metabolism; however, their physiological roles remain unclear. As genome-scale metabolic mod... read more
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  • Sridharan, G. V., E. Ullah, S. Hassoun and K. Lee (2015). "Discovery of substrate cycles in large scale metabolic networks using hierarchical modularity." BMC Systems Biology 9(1). doi: 10.1186/s12918-015-0146-2.
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