Background: High dose oral thiamine may have a role in treating
diabetes, heart failure, and hypermetabolic states. The purpose of this study was to
determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500
mg and 1500 mg doses in healthy subjects.
Smithline, Howard, Michael Donnino, and David J. Greenblatt.
"Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects." BMC
Clinical Pharmacology 12, no. 1 (12, 2012): 1-10.