%0 PDF %T Bench-top Fabrication of Silk Microneedles for Transdermal Drug Delivery. %A Diwan, Izzuddin. %8 2017-04-24 %R http://localhost/files/dr26z871d %X Abstract: Microneedles (MNs) are a form of transdermal drug delivery capable of delivering an antigen or vaccine in a painless fashion. Silk is a biodegradable and biocompatible polymer with good mechanical strength, offering a suitable material for the fabrication of MNs. The current fabrication of silk MNs is achieved through either clean-room based lithography or machine shop-based micromachining. In the present work, we investigated an alternative fabrication method that can be performed on the bench-top without the need for special facilities or equipment. Additionally we investigated drug release from these silk MNs in vitro, looking at different loadings and coatings of drugs to characterize release into the skin. In vivo studies investigated the use of silk MNs to deliver a model antigen, Ovalbumin, to illicit an immune response in rats.; Thesis (M.S.)--Tufts University, 2013.; Submitted to the Dept. of Biomedical Engineering.; Advisor: David Kaplan.; Committee: Qiaobing Xu, and Gary Leisk.; Keyword: Biomedical engineering. %[ 2022-10-12 %9 Text %~ Tufts Digital Library %W Institution