Luteolin as a therapeutic option for multiple sclerosis.
Theoharides, Theoharis C.
Abstract: Multiple sclerosis (MS) remains without an effective treatment
in spite of intense research efforts. Interferon-beta (IFN-β) reduces duration and
severity of symptoms in many relapsing-remitting MS patients, but its mechanism of
action is still not well understood. Moreover, IFN-β and other available treatments
must be given par... read moreenterally and have a variety of adverse effects. Certain naturally
occurring flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory
effects, including inhibition of activated peripheral blood leukocytes from MS
patients. Luteolin also inhibits mast cells, as well as mast cell-dependent T cell
activation, recently implicated in MS pathogenesis. Moreover, luteolin and
structurally similar flavonoids can inhibit experimental allergic allergic
encephalomyelitis (EAE), an animal model of MS in rodents. An appropriate luteolin
formulation that permits sufficient absorption and reduces its metabolism could be a
useful adjuvant to IFN-β for MS therapy.
Springer Open.read less
- Theoharides, Theoharis, "Luteolin as a therapeutic option for multiple sclerosis." Journal of Neuroinflammation 6, no. 1 (12, 2009): 1-3.