Determining the Function of Blm, FancM, and HelQ Helicases in Repair of Double Strand Breaks via Synthesis Dependent Strand Annealing.

Cox, Julie C.


  • In Drosophila, DNA double-strand breaks that occur in the soma and the pre-meiotic germline are frequently repaired by homologous recombination via synthesis-dependent strand annealing (SDSA). Several different helicases, including Blm, FancM, and HelQ, are thought to be involved in SDSA. Their importance is underscored by the consequences associated with their absence, including genome instabilit... read more
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