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In Drosophila, DNA double-strand breaks that occur in the soma and the pre-meiotic germline are frequently repaired by homologous recombination via synthesis-dependent strand annealing (SDSA). Several different helicases, including Blm, FancM, and HelQ, are thought to be involved in SDSA. Their importance is underscored by the consequences associated with their absence, including genome instability ... read moreand cancer. However, their exact roles and the ways in which they might interact with one another are not well understood. Here, we report the results of experiments designed to elucidate the in vivo roles of these helicases.read less
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