Cyclin-dependent kinase-5 regulates the polarized trafficking of dense-core vesicles in C. elegans motor neurons.

Goodwin, Patricia.


  • Abstract: Cyclin-dependent kinase-5 (CDK-5) is a serine/threonine kinase with many important functions in neurons, including regulation of development, protein transport, synaptic transmission and plasticity, and neurodegeneration. Aberrant activation of CDK-5 can cause neuronal death, and inhibition of CDK-5 is protective in animal models of Alzheimer's disease, prion protein disease, and Hunting... read more
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