Hydrogel Facilitated Field-Effect Transistor Biosensors
Vo, Richard.
2021
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Thesis
(Ph.D.)--Tufts University, 2021.
Submitted to the Dept. of Biomedical Engineering.
Advisor: Xiaocheng Jiang.
Committee: Fiorenzo Omenetto, Sameer Sonkusale, and Shannon Stott.
Keyword: Biomedical engineering.
Field-effect transistors (FETs) have been exploited as label-free transducers for ultrasensitive biomolecular detection with ... read moreunprecedented spatiotemporal resolution. FETs function by detecting the variation of charge or electric potential of a target analyte and represent a more general and less invasive platform that could potentially work for all charged species, making FETs are an excellent candidate for bioelectronic interfacing. At the interface between biological and electronic systems, FETs can provide a real-time, label free platform for detection of sensitive biologically derived signals that are difficult to achieve with other methods. While tremendous progress has been made in the design and development of FETs for biosensing applications, the effective signal coupling and long-term integration between the two has limited their translation toward practical biomedical applications. To address these limitations, we introduce the use of biofunctional hydrogels to facilitate the integration between sensitive bioreceptors and FET sensors. Hydrogel integration provides an approach to functionalize FET sensors that is compatible with both living and electronic systems, providing a favorable microenvironment and improving their long-term performance. The hydrogel integration is demonstrated to improve signal transduction through the intimate coupling of the two systems and represents a critical step towards overcoming many key limitations for the detection of biologically significant signals. The development of hydrogel field-effect transistor biosensors represents a broad platform that can have a large impact on many applications, such as point-of-care diagnostics, personalized medicine, long-term bioelectronic interfacing, and biological information processing.read less - ID:
- d791sw57f
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