The Role of Histone Modifications in Chromosome Breakage and Translocation.

Burman, Bharat.


  • Abstract: Chromosome translocations are genetic hallmarks of most cancer cells. Translocations require the formation of DNA double-strand breaks (DSBs) at two or more genomic loci, followed by the illegitimate joining of broken chromosomal ends through DNA repair. There is increasing evidence that translocations occur at non-random sites in the genome, suggesting that certain regions of the genome... read more
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