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Abstract: We have developed FusionSeq to identify fusion transcripts from paired-end RNA-sequencing. FusionSeq includes filters to remove spurious candidate fusions with artifacts, such as misalignment or random pairing of transcript fragments, and it ranks candidates according to several statistics. It also has a module to identify exact sequences at breakpoint junctions. FusionSeq detected known ... read moreand novel fusions in a specially sequenced calibration data set, including eight cancers with and without known rearrangements.
Keywords: Fusion Transcript, Junction Sequence, Chimeric Transcript, Fusion Junction, Transcript Fragment.
Springer Open.read less
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