Mechanisms of Actomyosin-Mediated T Cell Activation.

Brewka, Rosemary.


  • Abstract: Antigen recognition by the T cell receptor (TCR) complex and engagement of costimulatory ligands, such as CD28 and Very Late Antigen-4 (VLA-4), are essential for sustained activation of T lymphocytes. These receptor interactions induce extensive cytoskeletal rearrangement that forms the immune synapse and shapes discrete nucleation sites of activating SLP-76 (SH2 domain containing leukoc... read more
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