%0 PDF %T Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma. %A Heilmann, Romy M.; McNiel, Elizabeth A.; Grützner, Niels.; Lanerie, David J.; Suchodolski, Jan S.; Steiner, Jörg M. %D 2017-04-24T12:24:22.118Z %8 2017-04-24 %R http://localhost/files/d217r1891 %X Background: Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of TCC/PCA and improve patient survival would be useful. S100A8/A9 (calgranulin A/B or calprotectin) and S100A12 (calgranulin C) are expressed by cells of the innate immune system and are associated with several inflammatory disorders. S100A8/A9 is also expressed by epithelial cells after malignant transformation and is involved in the regulation of cell proliferation and metastasis. S100A8/A9 is up-regulated in human PCA and TCC, whereas the results for S100A12 have been ambiguous. Also, the urine S100A8/A9-to-S100A12 ratio (uCalR) may have potential as a marker for canine TCC/PCA. Aim of the study was to evaluate the diagnostic accuracy of the urinary S100/calgranulins to detect TCC/PCA in dogs by using data and urine samples from 164 dogs with TCC/PCA, non-neoplastic urinary tract disease, other neoplasms, or urinary tract infections, and 75 healthy controls (nested case-control study). Urine S100A8/A9 and S100A12 (measured by species-specific radioimmunoassays and normalized against urine specific gravity [S100A8/A9USG; S100A12USG], urine creatinine concentration, and urine protein concentration and the uCalR were compared among the groups of dogs.; Keywords: Biomarker, Calprotectin, Diagnostic accuracy, S100A8/A9, S100A12, Transitional cell carcinoma.; Springer Open. %[ 2018-10-09 %9 Text %~ Tufts Digital Library %W Institution