Effect of omega-3 fatty acids on toll-like receptor 4-mediated macrophage inflammation and its regulation.

Honda, Kaori.


  • Abstract: Macrophages are a major source of pro-inflammatory factors in the arterial intima and play a central role in the development of atherosclerotic plaque. Macrophages express toll-like receptor 4 (TLR4), a plasma membrane receptor, which when activated triggers the nuclear factor &kappaB; (NFκB) and mitogen-activated protein kinase signaling pathways leading to the production of pro-inf... read more
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