Human endothelial cells secrete neurotropic factors to direct axonal growth of peripheral nerves.

Grasman, Johnathan M.

Kaplan, David, 1953-


  • Understanding how nerves spontaneously innervate tissues or regenerate small injuries is critical to enhance material-based interventions to regenerate large scale, traumatic injuries. During embryogenesis, neural and vascular tissues form interconnected, complex networks as a result of signaling between these tissue types. Here, we report that human endothelial cells (HUVECs) secrete brain-derive... read more
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  • Grasman, Jonathan M., and David L. Kaplan. "Human Endothelial Cells Secrete Neurotropic Factors to Direct Axonal Growth of Peripheral Nerves." Scientific Reports 7, no. 1 (June 22, 2017). doi:10.1038/s41598-017-04460-8.
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