Description |
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Introduction: Lineage tracing studies in mice have revealed the
localization and existence of lineage-restricted mammary epithelial progenitor cells
that functionally contribute to expansive growth during puberty and differentiation
during pregnancy. However, extensive anatomical differences between mouse and human
mammary tissues preclude ... read morethe direct translation of rodent findings to the human
breast. Therefore, here we characterize the mammary progenitor cell hierarchy and
identify the anatomic location of progenitor cells within human breast
tissues.
Keywords: analysis of variance, basal progenitor cells, bovine serum
albumin, cytokeratin, 3,3-diaminobenzidine, 4′,6-diamidino-2-phenylindole, Dulbecco's
modified Eagle's medium, dimethyl sulfoxide, epidermal growth factor, estrogen
receptor alpha, fluorescence-activated cell sorting, luminal progenitor cells, mature
basal, myoepithelial, mammary epithelial cells, mature luminal, mammary lineage
negative, phosphate-buffered saline, progesterone receptor, smooth muscle actin,
spanning-tree progression analysis of density-normalized events, terminal ductal
lobular units.
Springer Open.read less
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Citation |
- Arendt, Lisa, Patricia J. Keller, Adam Skibinski, Kevin
Goncalves, Stephen P. Naber, Rachel J. Buchsbaum, Hannah Gilmore, Steven E. Come, and
Charlotte Kuperwasser. "Anatomical localization of progenitor cells in human breast
tissue reveals enrichment of uncommitted cells within immature lobules." Breast
Cancer Research 16, no. 0 (10, 2014): 1-16.
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