H. pylori colonization and risk of diabetes: an ancillary analysis in the Diabetes Prevention Program.
there are conflicting reports on the association between H. pylori infection and
clinical manifestations of the metabolic syndrome, we aimed to prospectively investigate
the association between H. pylori infection and risk of incident diabetes in adults at
high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study.
In a nested case-control study ... read moreconducted among 421 adults with newly diagnosed diabetes
and 421 matched controls in the DPP study, we examined the association between
serostatus of H. pylori at baseline (collected when all participants were free of
diabetes) and risk of incident diabetes over a mean follow-up period of 2.6 years. We
also examined the cross-sectional association between H. pylori infection and insulin
sensitivity, insulin secretion and the oral disposition index at baseline. Analyses were
adjusted for matching variables (age, sex, race, DPP intervention arm and length of
follow up) and potential confounders. At baseline, H. pylori infection was present in
40% of cases and 39% of controls. After adjusting for matching factors, there was no
association between H. pylori infection and incident diabetes (odds ratio [OR] of 1.04
(95% CI, 0.77 to 1.40). Further adjustment for body mass index at baseline did not
change the relationship (OR 1.04; 95% CI, 0.76 to 1.42). H. pylori infection was
negatively associated with insulin sensitivity index and disposition index, and
positively associated with insulin secretion, but these findings were not statistically
significant. In adults at high risk for diabetes, H. pylori infection was not associated
with of incident diabetes. Insulin sensitivity, insulin secretion and oral disposition
index at baseline did not significantly differ between participants with H. pylori
infection or without.
Thesis (M.S.)--Tufts University, 2014.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Anastassios Pittas.
Committee: Jason Nelson, Jessica Paulus, and Robin Ruthazer.
Keywords: Medicine, and Microbiology.read less
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