Innate Immunity in Chagas Heart Disease: The Role of Cathelicidin

Macedo, Nicholas.


  • Abstract: Cardiac stem/progenitor cells (CPCs) can repair the injured heart by replacing dead cells and/or secreting paracrine factors that trigger cell survival. Whether CPCs also work to prevent myocardial injury is less appreciated. We observed that CPCs, unlike cardiac myocytes and fibroblasts, are resistant to infection by the obligate intracellular parasite Trypanosoma cruzi, which causes Ch... read more
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