Preclinical Studies of the Pathogenesis and Therapy of Ph+ Leukemia in Mice: A Critical Role for Gab2 and Development of a Novel Inhibitor of ABL T315I.

Chan, Wayne.


  • Abstract: Dysregulated tyrosine kinases (TKs) are the hallmark of nearly all cases of myeloproliferative neoplasms (MPNs). The most widely studied of these TKs is BCR-ABL1, a known direct molecular cause of both CML and Ph+ B-ALL. The cardinal role of BCR-ABL1 in the pathogenesis of CML came from the development of a bone marrow transduction/transplantation mouse model, in which retrovirally-directed ... read more
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