Parkinsonism-associated protein DJ-1 is an antagonist, not an eraser, for protein glycatioin

Gao, Qingzeng


  • Glycation is a spontaneous protein modification associated with aging and human disease. The Parkinson-associated protein DJ-1 is a multi-purpose enzyme that has been reported to have deglycase activity that can reverse glycation in proteins, making it an attractive therapeutic target. In this work, we provide a rigorous evaluation of DJ-1 activity and find that DJ-1 cannot be considered a glycation ... read more
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