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Abstract: Understanding the mechanisms that coordinate cell migration, differentiation, and proliferation is a key goal in developmental biology. Alongside biochemical signals, it has recently been demonstrated that endogenous ion currents and voltage gradients play a role in determining cell fate. Here, we expand upon the knowledge by determining a role of biophysical events in cement gland ... read moreformation. To investigate how biophysical events affect cement gland development in vivo, we overexpressed inwardly rectifying potassium channel Kir4.1 to induce hyperpolarization. Characterizing the phenotype revealed an increase in ectopic expression patterns and abnormally shaped endogenous cement glands. A Ca2+ influx through voltage gated calcium channels may be responsible for transducing voltage potentials into changes in cell behavior during cement gland development. The results demonstrate a new role for transmembrane voltage potentials as a crucial upstream regulator in cement gland formation.read less
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