Towards creating an extended metabolic model (EMM) for E. coli using enzyme promiscuity prediction and metabolomics data.

Amin, Sara A.

Chavez, Elizabeth.

Porokhin, Vladimir.

Nair, Nikhil U.

Hassoun, Soha.

2019

Description
  • Background: Metabolic models are indispensable in guiding cellular engineering and in advancing our understanding of systems biology. As not all enzymatic activities are fully known and/or annotated, metabolic models remain incomplete, resulting in suboptimal computational analysis and leading to unexpected experimental results. We posit that one major source of unaccounted metabolism is promiscuous ... read more
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