Functional analysis and therapeutic targeting of AKT isoforms in BRAF mutant melanoma

McRee, Siobhan.


  • Abstract: Despite recent advances, metastatic melanoma remains the deadliest form of skin cancer, and new therapeutic strategies are urgently needed. The PI3K/AKT pathway is known to promote tumor progression and metastatic dissemination in many cancer types, including melanoma. PI3K/AKT signaling is hyperactivated in many melanomas, often through loss of the negative regulator PTEN, which occurs ... read more
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