Pyroptosis and Pyroptosis Like: Two stories of Macrophage death against bacterial invaders

Liu, Beiyun.


  • Abstract: The re-discovery of caspase-11 led to the refinement of the functions of both caspase-11 and caspase-1. The current consensus is that caspase-11 is both the initiator and executioner caspase for cell death upon binding by bacterial lipopolysaccharide present in the cytosol. Caspase-1, on the other hand, is the executioner caspase for cleavage and activation of various IL-1 family of ... read more
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