Investigating the patterning role of the hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) during cardiogenesis in Xenopus laevis.

Epiney, Justine.

2017

Description
  • This thesis focuses on the embryonic role of the hyperpolarization-activated cyclic-nucleotide gated channel 4 (HCN4). HCN4 belongs to the HCN family of proteins, which is composed of 4 isoforms (HCN1-4), and regulates the spontaneous excitability of cells in the heart and nervous system. Specifically, HCN4, the main isoform in the heart, is responsible for the initial, spontaneous depolarization ... read more
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