Uncovering the roles of B lymphocytes in the NOD mouse model of type 1 diabetes through genetic engineering and therapeutic targeting

Wang, Qiming.


  • β-cell destruction in type 1 diabetes (T1D) is considered a T-cell mediated autoimmune manifestation, but based on studies in the NOD mouse model, B-lymphocytes also play a critical role in disease development. They do so by serving as a preferential subset of pathogenic antigen resenting cells (APC) that expand diabetogenic T cells. Immunological tolerance induction mechanisms that normally ... read more
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