PAR1 Action in Tumor Development and Metastasis.

Yang, Eric.


  • Abstract: Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor that is not expressed in normal breast epithelia, but is up-regulated in invasive breast carcinomas. In the present study, we found that matrix metalloprotease-1 (MMP-1) activates the PAR1-Akt survival pathway in breast carcinoma cells. This process is blocked by a cell-penetrating lipopeptide `pepducin', P1pal-7, a pot... read more
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