The Integrated Role of Wnt Signaling, mTOR Signaling and Glutamate Metabolism as a Possible Drug Target for Epilepsy in HBP1-/- Mice

Alkhelb, Dalal.

2018

Description
  • Abstract: We have shown that Wnt signaling is activated in the hippocampus 5 days following status epilepticus (SE), and that Wnt signaling activates a Warburg-like metabolic program. We hypothesized that Wnt-signaling induced Warburg metabolism contributes to the ratio of GABA to glutamate, which is a critical factor in the progression to chronic seizures and whose syntheses derive from TCA ... read more
This object is in collection Creator department Thesis Type Genre Permanent URL
ID:
bn999k71v
Component ID:
tufts:25400
To Cite:
TARC Citation Guide    EndNote