The Integrated Role of Wnt Signaling, mTOR Signaling and Glutamate Metabolism as a Possible Drug Target for Epilepsy in HBP1-/- Mice

Alkhelb, Dalal.


  • Abstract: We have shown that Wnt signaling is activated in the hippocampus 5 days following status epilepticus (SE), and that Wnt signaling activates a Warburg-like metabolic program. We hypothesized that Wnt-signaling induced Warburg metabolism contributes to the ratio of GABA to glutamate, which is a critical factor in the progression to chronic seizures and whose syntheses derive from TCA ... read more
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