Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design.

Boghigian, Brett A.

Shi, Hai.

Lee, Kyongbum.

Pfeifer, Blaine A.

2010

Description
  • Background: Microbial hosts offer a number of unique advantages when used as production systems for both native and heterologous small-molecules. These advantages include high selectivity and benign environmental impact; however, a principal drawback is low yield and/or productivity, which limits economic viability. Therefore a major chal... read more
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  • Boghigian, Brett, Hai Shi, Kyongbum Lee, and Blaine A. Pfeifer. "Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design." BMC Systems Biology 4, no. 1 (12, 2010): 1-17.
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bc386w814
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