Novel Modulators of Rickets Receptor Mediated Signaling In Vitro and In Vivo.

Harwood, Bejamin.


  • Abstract: My initial efforts focused on extending the utility of membrane tethered ligands (MTLs) to enable exploration of the function of rickets (rk), a Drosophila melanogaster G protein-coupled receptor (GPCR). Rk mediates wing expansion, cuticle hardening, and melanization during the transition from the pupal to adult stages. The endogenous rk ligand is bursicon, a heterodimeric cystine-knot p... read more
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