Identification of Pathogenic Lymphocyte Subsets in Ankylosing Spondylitis.

Sharma, Nihaarika.

2018

Description
  • Killer immunoglobulin-like receptors (KIRs) may play a role in the pathogenesis of ankylosing spondylitis (AS). KIR3DL2 binds to HLA-B27 homodimers and genetic associations with AS have been reported for KIR3DS1/DL1 and KIR2DL5. KIR expression is not limited to Natural Killer (NK) cells and has been demonstrated for other innate and adaptive lymphocyte subsets as well. We hypothesize that the prev... read more
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