A role for IGF-II in cartilage development and disease.

Uchimura, Tomoya.

2015

Description
  • Abstract: Proper cartilage development is critical for normal postnatal long bone growth, however, precise mechanisms how early postnatal long bone growth is regulated have not been fully understood. Here, we demonstrate that IGF-II is required for postnatal cartilage development and long bone growth. The Igf-II null bone has reduced longitudinal and lateral growth, delayed secondary ossification ... read more
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tufts:20605
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