Late Oxygen Exposure and Retinopathy of Prematurity: A Propensity Score Analysis.
Objective: It is unclear whether late oxygen exposure after 31-32 weeks postmenstrual
age (PMA) is associated with retinopathy of prematurity (ROP). The study aim is to
explore the association of late oxygen exposure with development of ROP in preterm
infants. Patients and Methods: Clinically important variables for preterm infants
weighing <1500g at birth were recorded as part of t... read morehe Vermont Oxford Network (VON)
registry. Data were prospectively collected for 1003 premature infants born between 23
and 28 weeks gestation. Exposure to oxygen at 36 weeks PMA, during phase II of ROP
pathogenesis, was recorded. Multivariable logistic regression models were created to
examine the effects on the risk of severe ROP. A propensity score for late oxygen
exposure was used to control for potential confounding variables. Results: Infants who
received late oxygen had lower birth weights and gestational ages. They were more likely
to be male, receive oxygen at day of life 28, have a patent ductus arteriosis (PDA), a
PDA ligation, respiratory distress syndrome (RDS), pneumothorax, and late bacterial
sepsis compared to those who did not receive late oxygen. After adjustment by propensity
score stratified into quintiles for late oxygen therapy, infants who were still
receiving oxygen at 36 weeks PMA were twice as likely as those who did not receive late
oxygen to develop severe ROP [OR 2.00 (95%CI 1.29-3.09); p=0.002]. Conclusion: Late
oxygen administered at 36 weeks PMA during phase II of ROP pathogenesis, might increase
the risk of developing ROP in preterm infants. More research is needed to confirm this
association and to further elucidate the
Thesis (M.S.)--Tufts University, 2012.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Jonathan Davis.
Committee: John Griffith, Jessica Paulus, Olaf Dammann, and Minghua Chen.
Keyword: Health sciences.read less