Late Oxygen Exposure and Retinopathy of Prematurity: A Propensity Score Analysis.
Lee, Jennifer.
2012
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Abstract: Objective: It is unclear whether late oxygen exposure after 31-32 weeks postmenstrual age (PMA) is associated with retinopathy of prematurity (ROP). The study aim is to explore the association of late oxygen exposure with development of ROP in preterm infants. Patients and Methods: Clinically important variables for preterm infants weighing <1500g at birth were recorded as part of the... read moreVermont Oxford Network (VON) registry. Data were prospectively collected for 1003 premature infants born between 23 and 28 weeks gestation. Exposure to oxygen at 36 weeks PMA, during phase II of ROP pathogenesis, was recorded. Multivariable logistic regression models were created to examine the effects on the risk of severe ROP. A propensity score for late oxygen exposure was used to control for potential confounding variables. Results: Infants who received late oxygen had lower birth weights and gestational ages. They were more likely to be male, receive oxygen at day of life 28, have a patent ductus arteriosis (PDA), a PDA ligation, respiratory distress syndrome (RDS), pneumothorax, and late bacterial sepsis compared to those who did not receive late oxygen. After adjustment by propensity score stratified into quintiles for late oxygen therapy, infants who were still receiving oxygen at 36 weeks PMA were twice as likely as those who did not receive late oxygen to develop severe ROP [OR 2.00 (95%CI 1.29-3.09); p=0.002]. Conclusion: Late oxygen administered at 36 weeks PMA during phase II of ROP pathogenesis, might increase the risk of developing ROP in preterm infants. More research is needed to confirm this association and to further elucidate the mechanisms.
Thesis (M.S.)--Tufts University, 2012.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Jonathan Davis.
Committee: John Griffith, Jessica Paulus, Olaf Dammann, and Minghua Chen.
Keyword: Health sciences.read less - ID:
- 9p290n49h
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