Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1.

Kritzer, Joshua A.

Kamens, Alissa.

Mientkiewicz, Kaley.

Eisert, Robyn J.

Walz, Jenna A.

Mace, Charles R.

2017.

Description
  • Recycling of receptors from the endosomal recycling compartment to the plasma membrane is a critical cellular process, and recycling is particularly important for maintaining invasiveness in solid tumors. In this work, we continue our efforts to inhibit EHD1, a critical adaptor protein involved in receptor recycling. We applied a diversity-oriented macrocyclization approach to produce cyclic pepti... read more
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  • Kamens, A., Mientkiewicz, K., Eisert, R.J., Walz, J.A., Mace, C.R., Kritzer, J.A. Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg. Med. Chem. Sept. 2017. https://doi.org/10.1016/j.bmc.2017.09.007.
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9p290n36f
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