The role of the NMDA receptor in mediating aggression during withdrawal from ethanol in outbred male mice

Tayeh, Jillian Katherine

2013

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  • Ethanol withdrawal syndrome, characterized by glutamatergic hyperexcitability in the brain, is a defining characteristic of alcohol dependence. Glutamate hyperexcitability and an upregulation of NMDA receptors have been observed in the brains of mice in withdrawal from ethanol. The present study examined the effects of the uncompetitive NMDA receptor antagonist memantine on aggression during withd... read more
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