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Abstract: Detection
of circulating cancer cells is of major importance to epithelial and blood based
cancers. In epithelial cancers, the presence of circulating tumor cells (CTC) correlates
with metastatic burden and shortened overall survival. For lymphoma, a cancer of the
blood and lymph nodes, relapse is thought to be caused by residual lymphoma cells hiding
in bone marrow and lymph node m... read moreicroenvironments (ME). Quantifying the number of lymphoma
cells entering circulation would be a direct measure of drug efficacy and provide a
means to assess individual chemotherapy treatment. The objective of this thesis was to
assess the potential to use microfluidic confocal flow cytometry to discriminate
cancerous cells from white blood cells based on differences in backscattered light at
different wavelengths. In particular, backscatter flow cytometry's utility in an
in-vitro lymphoma model, and breast cancer mouse model was
assessed.
Thesis (M.S.)--Tufts University,
2016.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Irene
Georgakoudi.
Committee: Irene Georgakoudi, Andreas
Klein, and Qiaobing Xu.
Keywords: Biomedical
engineering, and Optics.read less
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