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In this study, the complexities of the cardiac infarct microenvironment were modeled with 3D silk scaffolds to understand how CPC proliferation and differentiation are affected by infarct composition and oxygen tension. These models were also used to evaluate how preconditioning and implantation strategies augment the regenerative potential of CPCs. Finally the ion channels of human CPCs were ... read morecharacterized to understand their prevalence and variation for the development of hyperpolarization differentiation strategies.read less
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