Rational Design of Cyclic Peptides for Inhibiting Cancer Proliferation

Ling, Yingjie

2021

Description
  • The association between cyclin-dependent kinases regulatory subunit 1 (Cks1) and S-phase kinase-associated protein 2 (Skp2) is required for the most efficient degradation of p27Kip1, a cyclin-dependent kinase inhibitor that halts cell cycle progression. In cancer cells, Cks1 is often over-expressed, while p27Kip1 over-degraded. Therefore, a specific and potent inhibitor targeting the Cks1–Skp2 ... read more
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