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Abstract: Recent studies have implicated potentially significant roles
for astrocytes in the pathogenesis of neurodevelopmental disorders. Astrocytes
undergo a dramatic maturation process following early differentiation from which
typical morphology and important functions are acquired. Despite significant progress
in understanding their ... read moreearly differentiation, very little is known about how
astrocytes become functionally mature. In addition, whether functional maturation of
astrocytes is disrupted in neurodevelopmental disorders and the consequences of this
disruption remains essentially unknown. In this review, we discuss our perspectives
about how astrocyte developmental maturation is regulated, and how disruption of the
astrocyte functional maturation process, especially alterations in their ability to
regulate glutamate homeostasis, may alter synaptic physiology and contribute to the
pathogenesis of neurodevelopmental disorders.
Keywords: Astrocyte, Developmental maturation, Neuronal to astrocyte
signaling, Glutamate, Glutamate transporter, GLT1, Developmental
disorder.
Springer Open.read less
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