The Role of TLR7/8 in Autoantibody Production and Granulopoiesis in Murine SLE.

Andersson, Shauna.


  • Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by the presence of IgG autoantibodies to nuclear antigens in the sera of patients. Utilizing a novel SLE mouse model "564Igi" with knocked-in genes for the heavy and light chain of an anti-RNA autoantibody, our laboratory has previously reported that autoantibody production in 564Igi is T cell indepe... read more
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