A Possible link between Aβ42 production associated with Alzheimer's Disease and SIRT1.

Barry, Walter.


  • Alzheimer's, a neurological disease commonly associated with aging, is believed to be driven by the improper clearance and thereby buildup of the 42 residue Aβ peptide. SIRT1 has a demonstrated role as a regulator of metabolism and the process of aging. Prior in virto experiments have shown a protective role of SIRT1 against neurodegenerative diseases like Alzheimer's. Here we show increased levels ... read more
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