The Mechanism of Large-Scale CAG Repeat Expansion.

Dinter, Teresa.

2015

Description
  • Nearly 30 genetic diseases are caused by the repetition of a short sequence of 2-9 base pairs, known as microsatellites. These microsatellite repeats occur in humans normally; however disease symptoms become apparent once a certain repeat threshold is reached. Usually, these diseases follow a phenomenon known as genetic anticipation, in which each subsequent generation experiences increased diseas... read more
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