Background: Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy
and hyperplasia as well as elevated adipose tissue and systemic inflammation.
Multipotent stem cells isolated from adult adipose tissue can differentiate into
adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbers,
obesity, and inflamm ation. ... read moreCurrently, information is lacking regarding regulation of
adipose stem cell numbers as well as leptin-induced inflammation and its signaling
pathway in ob/ob mice.