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Background: Disease taxonomies have been designed for many applications, but they tend not to fully incorporate the growing amount of molecular-level knowledge of disease processes, inhibiting research efforts. Understanding the degree to which we can infer disease relationships from molecular data alone may yield insights into how to ultimately construct more modern taxonomies that integrate both ... read morephysiological and molecular information.
Keywords: Disease Ontology inference, Disease tree inference, Pairwise disease similarity, Disease gene association, Medical Subject Headings tree, Disease Ontology, Hierarchical clustering, Parent Promotion.
Springer Open.read less